Ceibos did not compete in the 2021 edition of the competition, having been replaced by the Argentine Rugby Union with the Jaguares XV.

The top 4 clubs at the end of the regular season moved on to the championship playoffs.

The championship was contested between the top four regular season clubs in a knockout tournament.

The second half of the regular season and the playoffs of the competition was held at Estadio Charrúa in Montevideo.

[5] The following are the match results for the 2021 Super Liga Americana de Rugby regular season: The top try and point scorers during the 2021 Súper Liga Americana de Rugby season are:[6] Last updated Oct 6, 2021