They were led by head coach Darin Hendrickson, in his 13th season at Saint Louis.

The 2020 Saint Louis Billikens baseball team notched a 10–6 (0–0) regular season record.

The season prematurely ended on March 12, 2020, due to concerns over the COVID-19 pandemic.

The Atlantic 10 baseball coaches' poll was released on February 18, 2021.

Saint Louis was picked to finish fifth the Atlantic 10 regular season championship.