[2][3] The team was led by 4th year head coach Ernie McCook, and played their home games at Ram Stadium in Shepherdstown, WV.
On December 17, Junior QB Tyson Bagent won the Harlon Hill Trophy, as most valuable player in NCAA Division II for the 2021 season.
[4][5] Shepherd advanced to the NCAA Division II Football Championship as the #2 seed in Super Region 1.
In the second round against Notre Dame (OH), the Rams won 38–34, on a Tyson Bagent 23 yard touchdown pass with two seconds remaining.
[6] In the quarterfinal round against Kutztown, Bagent threw a 42 yard touchdown pass as time expired, resulting in a 30–28 win for Shepherd.