The 2021 Sibiu Cycling Tour was a road cycling stage race that took place between 3 and 6 July 2021 in and around the city of Sibiu, Romania.

It was the 11th edition of the Sibiu Cycling Tour and a category 2.1 event on the 2021 UCI Europe Tour.

[1] Two UCI WorldTeams, four UCI ProTeams, twenty-one UCI Continental teams, and the Romanian national team made up the twenty-eight teams that participated in the race.

Only four of these teams did not enter a full squad of six riders; Amore & Vita, D'Amico–UM Tools, Nippo–Provence–PTS Conti, and Yoeleo Test Team p/b 4Mind each entered a squad of five riders.

With one further non-starter, D'Amico–UM Tools was reduced to four riders, meaning 163 riders started the race.