‌The 2021 South and Central American Women's Handball Championship was the second edition of the championship and held from 5 to 9 October 2021 at Asunción, Paraguay under the aegis of South and Central America Handball Confederation.

It was the first time in history that the championship is organised by the Paraguay Handball Confederation.

It also acted as the qualification tournament for the 2021 World Women's Handball Championship, with the top three teams qualifying.

[2] Brazil won the tournament for the second time after a finals win over Argentina.

[6] The All Star Team was announced on 11 October 2020.