The Argonauts improved on their 4–14 record from their previous season in 2019 with a win in week 10 against the Ottawa Redblacks on October 6, 2021.

[6][7] On June 15, 2021, the league released the revised 14-game schedule with regular season play beginning on August 5, 2021.

[14] The team acquired an additional fourth-round selection after trading Shawn Lemon to the BC Lions in exchange for Davon Coleman.

[8] [17] The Argonauts initially had a schedule that featured 18 regular season games beginning on June 19 and ending on October 30.

[19] The CFL announced on September 2, 2021, that the game was rescheduled for Tuesday, November 16, 2021, where the Argonauts originally had a bye week.