Figure Skating announced that, in light of the COVID-19 pandemic in the United States, the event would be moved to Las Vegas, Nevada.

[3] After the success of 2020 Skate America's bubble environment in the same arena, USFSA implemented the same structure for the 2021 U.S. Championships.

Figure Skating Championship Series, to replace Regionals and Sectionals due to skaters' delayed training times resulting from the COVID-19 pandemic.

Skaters can select up to two competitions and will then be advanced to Nationals or the High Performance Development Team based on their highest score, rather than their placement.

The competition was used to give senior skaters byes to Nationals and was used in the selection of future international assignments, as conditions allowed.

[6] As of November 2, the Championships Series was replaced by a virtual qualifying competition, resulting in changes to the qualification structure.

Video submissions to the series will be available on public format, including the US Figure Skating Fan Zone and Peacock Premium.

[20] Additionally, due to the bubble environment, there were specific entry and departure dates for each of the senior disciplines, with all junior-level skaters arriving on January 18.

After three senior pairs teams training under the same coach came into contact with a COVID-positive case, they voluntarily chose to withdraw out of precaution, whereas senior ice dance team Christina Carreira / Anthony Ponomarenko appeared to be asked to withdraw by the federation.

In addition, coach Tom Zakrajsek was unable to travel to the event due to contracting COVID-19 in early January and one of his students, Paige Rydberg, also tested positive upon arrival in Las Vegas; despite this, no contact tracing protocols were enacted, with the remaining athletes from Zakrajsek's training group and rink being allowed to compete.