The men's road race of the 2021 UCI Road World Championships was a cycling event that took place on 26 September 2021 from Antwerp to Leuven, Belgium.

[1][2] Defending champion Julian Alaphilippe of France won the event in a solo victory.

[3] Qualification was based mainly on the UCI World Ranking by nations as of 17 August 2021.

The number of cyclists per nation is shown in parentheses.

[6] Of the race's 194 entrants, 68 riders completed the full distance of 268.3 kilometres (166.7 mi).