Honours went to Niamh Fisher-Black from New Zealand of the SD Worx team with 34 points and four victories, ahead of French rider Évita Muzic, who also won four races for FDJ Nouvelle-Aquitaine Futuroscope.
A total of eight riders won races during the season, with the classification lead changing six times between Fisher-Black, Muzic, Novolodskaya, Sarah Gigante (Tibco–Silicon Valley Bank) and Emma Norsgaard Jørgensen (Movistar Team).
[2] Paris–Roubaix, which featured on the revised 2020 schedule after the suspension of racing due to the COVID-19 pandemic, also returned to the calendar, as did the RideLondon Classique after a year's absence.
[5] La Course by Le Tour de France was moved forward a further day in April 2021 to 26 June, due to departmental elections to be held in Côtes-d'Armor, and consisted of a route utilising part of the opening stage of the men's race.
[7] On 1 November 2020, the season-opening Cadel Evans Great Ocean Road Race was cancelled due to quarantine and border restriction issues attributed to the COVID-19 pandemic.
[13] The organisers of the Ronde van Drenthe announced that they had applied to the Union Cycliste Internationale (UCI) to move the race from the assigned date of 14 March to the last weekend of October.
[8] In May, the Open de Suède Vårgårda races were cancelled due to financial issues associated with the COVID-19 pandemic in Sweden.