They played their home games at the Los Angeles Memorial Coliseum and competed as members of the South Division of the Pac-12 Conference.

The official list of participants for the 2021 Senior Bowl included USC football player Marlon Tuipulotu (DT).

The official list of participants for the 2021 NFL Combine included USC football players to be announced soon.

at Sun Devil Stadium, Tempe, AZ at Los Angeles Memorial Coliseum, Los Angeles, CA at Los Angeles Memorial Coliseum, Los Angeles, CA at California Memorial Stadium, Berkeley, CA USC vs Opponents USC vs Pac-12 opponents Key: POS: Position, SOLO: Solo Tackles, AST: Assisted Tackles, TOT: Total Tackles, TFL: Tackles-for-loss, SACK: Quarterback Sacks, INT: Interceptions, BU: Passes Broken Up, PD: Passes Defended, QBH: Quarterback Hits, FR: Fumbles Recovered, FF: Forced Fumbles, BLK: Kicks or Punts Blocked, SAF: Safeties, TD : Touchdown

Trojans who attended the 2022 CFL Global Draft: Five members of the 2021 team were invited to participate in drills at the 2022 NFL Scouting Combine.