Rajeev Ram and Joe Salisbury defeated the defending champion Bruno Soares and his partner Jamie Murray in the final, 3–6, 6–2, 6–2 to win the men's doubles tennis title at the 2021 US Open.

It was the second major title for Ram and Salisbury as a team, following the 2020 Australian Open.

[1] Ram and Salisbury saved four match points en route to the title, in the quarterfinals against Matthew Ebden and Max Purcell.

[2] Soares and Mate Pavić were the defending champions,[3] but did not play together.

Pavić partnered Nikola Mektić, but lost in the first round to Nathaniel Lammons and Jackson Withrow.