Samantha Stosur and Zhang Shuai defeated Coco Gauff and Caty McNally in the final, 6–3, 3–6, 6–3 to win the women's doubles title at the 2021 US Open.

Zvonareva was scheduled to play partnering Jeļena Ostapenko, but Ostapenko withdrew from both the singles and doubles draws on the first day of the tournament.

1 doubles ranking from her partner Elise Mertens after Barbora Krejčíková lost in the first round.

She partnered Sara Errani, but lost in the first round to Gauff and McNally.

[4] Click on the seed number of a player to go to their draw section.