The 2021 V.League 2 (known as the LS V.League 2 for sponsorship reasons) was the 27th season of V.League 2, Vietnam's second tier professional football league.

[1] The season was suspended on 6 May 2021 due to an outbreak of a new highly contagious variant of the coronavirus in the country.

[2] It was announced in August that the season would resume on 20 November 2021.

[3] However, all V.League clubs voted on 21 August to cancel the season.

There will not be promotion/relegation since the season was abandoned.