The 2021 Valdosta State Blazers football team represented Valdosta State University as a member of the Gulf South Conference (GSC) during the 2021 NCAA Division II football season.

The Blazers played their home games at Bazemore–Hyder Stadium in Valdosta, Georgia.

The Blazers competed for the 2021 NCAA Division II Football Championship Game against Ferris State.

On August 12, 2020, Gulf South Conference postponed fall competition in 2020 for several sports due to the COVID-19 pandemic.

The Blazers did not compete in the 2020 season and opted out of spring competition.