The Hokies played their home games at Sandra D. Thompson Field in Blacksburg, Virginia.
The Hokies were led by thirteenth-year head coach Mike Brizendine.
They defeated Campbell in the first round before losing to West Virginia in a penalty shoot-out to end their season.
In the 2021 MLS SuperDraft, the Hokies had two players drafted:Daniel Periera and Kristofer Strickler.
[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.