The 2021 Vuelta Asturias Julio Alvarez Mendo was a road cycling stage race that took place between 30 April and 2 May 2021 in the Asturias region of northwestern Spain.

It was the 63rd edition of the Vuelta Asturias and was part of the 2021 UCI Europe Tour calendar as a category 2.1 event.

[1] One UCI WorldTeam, ten UCI ProTeams, and four UCI Continental teams made up the fifteen teams that participated in the race.

All but two teams fielded the maximum of seven riders: Team Novo Nordisk entered six and Team Medellín–EPM entered five.

There was a total of 102 riders that started the race.