It was held on 23 May 2021 in the titular region of southeastern Spain as a category 1.1 event on the 2021 UCI Europe Tour calendar.

[3] The 192.4-kilometre (119.6 mi) long race started in Los Alcázares and finished in Alcantarilla.

[3][4] It was won by Alcantarilla-born Antonio Jesús Soto (Euskaltel–Euskadi), who was part of the race's initial breakaway.

During the rain-soaked race, Soto dropped his breakaway companions on the last climb and soloed to victory, his first ever as a professional.

The chasing bunch finished just over half a minute after Soto, with Ángel Madrazo (Burgos BH) winning the sprint for second ahead of Gonzalo Serrano (Movistar Team), who rounded out the podium.