The Women's 4 × 200 metres relay at the 2021 World Athletics Relays was held at Silesian Stadium on 2 May.

[1] Prior to the competition, the records were as follows:[1] (Marion JonesNanceen PerryLatasha ColanderLatasha Jenkins) (Jura LevyShericka JacksonSashalee ForbesElaine Thompson) (Javianne OliverKortnei JohnsonDezerea BryantSha'carri Richardson) [1]