The Cowboys were led by eighth-year head coach Craig Bohl and played their home games at War Memorial Stadium.

They were invited to the Famous Idaho Potato Bowl, where they defeated Kent State.

Wyoming signed 19 players to scholarships during their recruiting period.

[1] Sources: Listed in the order that they were released Mountain West media days were held on July 21 and 22 at the Cosmopolitan of Las Vegas.

[9][10] Quarterback Tailback Fullback Wide receiver Tight end Offensive lineman Defensive lineman Linebackers Defensive backs Placekicker/Punter Longsnapper Legend Source[11] Source[12][13][14] Key: SOLO: Solo Tackles, AST: Assisted Tackles, TOT: Total Tackles, TFL: Tackles-for-loss, SACK: Quarterback Sacks, INT: Interceptions, BU: Passes Broken Up, QBH: Quarterback Hits, FF: Forced Fumbles, FR: Fumbles Recovered, BLK: Kicks or Punts Blocked, SAF: Safeties All-Mountain West teams were announced on November 30, 2021.