[19][20] With their three consecutive defeats without scoring a goal to open the Premier League campaign, the club dropped to 20th, sitting at the bottom of the table, which was their worst start to a season for 67 years.

[58] Arsenal announced their first signing of the summer transfer window on 10 June, with 19-year-old Brazilian forward Marquinhos joining the club on a long-term contract from Série A side São Paulo.

[61] On 27 June, the Gunners confirmed that 28-year-old American goalkeeper Matt Turner had joined the club from Major League Soccer side New England Revolution, and would wear the number 30 shirt.

[62][63] He wore the number one shirt and played every game as USA won the 2021 CONCACAF Gold Cup as hosts, keeping five clean sheets in the tournament, and earning the Golden Glove award.

[68][70] On 22 July, 25-year-old Ukrainian left-sided player and Arsenal supporter Oleksandr Zinchenko, who is comfortable operating in midfield and defence, joined the club on a long-term contract,[71][72][73] and would wear the number 35 shirt.

[75][76] On 2 August, Arsenal announced German goalkeeper Bernd Leno, who had made 125 appearances for the club in all competitions, joined fellow Premier League side Fulham on a permanent transfer.

[85] Spanish defender and academy graduate Héctor Bellerín, who had made 239 first-team appearances in all competitions and won three FA Cups with the club, joined La Liga side Barcelona on a permanent transfer.

[89][90][91] In the 85th minute, Saka's cross was deflected home by Marc Guéhi to ensure Arteta registered his 50th league victory,[90] making him the second-quickest manager to reach 50 top-flight wins for Arsenal after Arsène Wenger.

[118][119] Arteta became the 11th manager to have won the first five games of a Premier League season, after Kevin Keegan, Carlo Ancelotti, Alex Ferguson, Arsène Wenger, Alan Curbishley, José Mourinho, Manuel Pellegrini, Pep Guardiola, Maurizio Sarri, and Jürgen Klopp.

[129][130][131] At half-time, the news broke of the death of Queen Elizabeth II,[132] and Arsenal's players returned to the field wearing black armbands in respect, while a minute's silence was held before the start of the second half.

[133][134][135][136] The Europa League group stage match between Arsenal and Eredivisie side PSV Eindhoven, originally scheduled to be played on 15 September, was also postponed due to organisational issues.

[155][156][157] On 9 October, the club faced ninth-placed Liverpool,[158] a team that Arsenal had only won one of their last 14 Premier League matches against since the 2015–16 season and had failed to score in their past six meetings with in all competitions.

[167] Saka scored the winning goal from a tight angle in the 35th minute, assisted by Ødegaard; Leeds striker Patrick Bamford missed a penalty midway through the second half.

[176] The eight-game winning run was ended, as Xhaka's 11th-minute opener was cancelled out by Stuart Armstrong's second-half leveller, in the club's first draw in 28 Premier League matches since January 2022.

[111][192] Arsenal went on to face rivals Chelsea at Stamford Bridge on 6 November,[193] a match that saw manager Arteta reach 150 games in all competitions – the same number of appearances he made for the Gunners as a player.

[219] On 4 December, manager Arteta named a 27-man squad – including thirteen academy players – for the trip to the United Arab Emirates, where they would play two friendlies in the Dubai Super Cup.

[220] Two days later, Arsenal confirmed that striker Gabriel Jesus had undergone surgery to his right knee after suffering an injury during Brazil's World Cup group stage match against Cameroon on 2 December.

[225] The Gunners' first league action after the World Cup was a Boxing Day fixture at home against 16th-placed West Ham United, on the anniversary of Arteta's first game as Arsenal manager.

[265] Arsenal announced their first signing of the winter transfer window on 20 January with 28-year-old Belgian forward Leandro Trossard joining the club on a long-term contract from fellow Premier League side Brighton & Hove Albion.

[268][269] On transfer deadline day, 31 January, the Gunners announced that 31-year-old Italian midfielder Jorginho had joined the club from Premier League side Chelsea and would wear the number 20 shirt.

[284][285] James Tarkowski netted the only goal of the match in the 60th minute to clinch victory for the hosts, marking Arsenal's second Premier League defeat of the season and their first in the previous 14 games.

[309][310] Strikes from Ollie Watkins and Philippe Coutinho were cancelled out by Saka and Zinchenko's first Premier League goal,[311][309][310] before Jorginho's long-range shot and Martinelli's counter sealed a 4-2 victory, taking Arsenal two points clear of City with a game in hand.

[347][348][349] Arsenal had several chances to score in extra-time, but despite Manuel Ugarte receiving a second yellow card, the Portuguese side held out to force the game to penalties, which they won 5-3.

[349][348] Ahead of the last international break of the season, the Gunners played at home on 19 March against 12th-placed Crystal Palace,[350] who had sacked manager and former Arsenal captain Patrick Vieira two days previously.

[369][368][367] In stoppage time, Ramsdale produced a flying fingertip save to deny Salah's deflected curling shot, then kept out Ibrahima Konaté's effort from point-blank range.

[386][387] This marked the second time the club had four players (Saka, Martinelli, Ødegaard and Gabriel Jesus) reach double figures for goals in a Premier League season, after 2012–13.

[401] Arsenal lost 1-0, courtesy of an early goal from Taiwo Awoniyi; the result sealed Forest's place in the top flight, and allowed Manchester City to clinch the Premier League title with three games still to play.

[626][627] On 19 April 2022, Arsenal announced that they would travel to the United States in July to compete in the FC Series as part of their preparations during pre-season with matches against Orlando City and Chelsea.

[637] In order to prepare for the resumption of the Premier League following the mid-season World Cup break, Arsenal announced that they were going to partake in a warm-weather training camp in Dubai, United Arab Emirates in early December.

Twenty-eight players made appearances for Arsenal's first team during the season; six of them (Gabriel Magalhães, Martinelli, Ødegaard, Saka, White and Xhaka) each played at least 45 of the total 49 matches.