The 2022–23 season was the 125th in the history of Ascoli Calcio 1898 F.C.

The club participated in Serie B and Coppa Italia.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Win Draw Loss Source: Soccerway Source: Serie B The league fixtures were announced on 15 July 2022.