The regular season began on 10 November 2022 and concluded on 22 January 2023 with the Adelaide Giants winning the Claxton Shield over the Perth Heat.
Baxter Field was previously announced to be hosting the first Australian Baseball League All-Star Game since 2017, but was delayed due to the damage caused by the 2022 eastern Australia floods.
The game between Canberra Cavalry and Sydney Blue Sox scheduled for Sunday 23 January was rained out before play could begin.
Because that was the last Sunday of the regular season, the game could not be rescheduled, and both teams were awarded a half win per the League's rules.
Brisbane Bandits hosted Perth Heat for a best-of-three semi-final at Viticon Stadium (Holloway Field).
Despite Adelaide making the final four times since the ABL's inaugural season in 2010–11, a team from South Australia has not won the Claxton Shield since 1980.
Adelaide-born Jordan McArdle was named the Postseason MVP, hitting three home runs across in both of the Giants' Championship Series wins.