The 2022–23 Big 12 Conference women's basketball season began non-conference play on November 7, 2022.

The Big 12 Conference tournament is scheduled for March 9–10, 2023 at the Municipal Auditorium in Kansas City, Missouri.

[1] Source:[10] Ja’Mee Asberry (Baylor), Dre’Una Edwards (Baylor), Zakiyah Franklin (Kansas), Taiyanna Jackson (Kansas), Ana Llanusa (Oklahoma), Shaylee Gonzales (Texas), Taylor Jones (Texas), Sonya Morris (Texas), JJ Quinerly (West Virginia), Madisen Smith (West Virginia) Source:[11] Below is a table of notable midseason watch lists.

This is a list of games against ranked opponents only (rankings from the AP Poll): Team rankings are reflective of AP poll when the game was played, not current or final ranking † denotes game was played on neutral site Throughout the conference regular season, Big 12 Conference offices named two players (Player and Freshman) of the week each Monday.

*denotes overtime Six team from the conference were selected to participate.