[10] 16 July saw the club's first signing of the summer, Lewis Fiorini joining on a season-long loan from Manchester City.

[13] The club made its first permanent signing of the summer on 25 July, left back Dominic Thompson joining from Brentford for an undisclosed fee.

Back in the league, on 13 August, Blackpool lost at home to Swansea City by virtue of an 87th-minute strike.

Blackpool faced Queens Park Rangers at Loftus Road on 16 August, and returned home with all three points after Josh Bowler's goal in first-half injury time.

Josh Bowler opened the scoring, while Blackpool's other goals came from Jerry Yates and Theo Corbeanu for the second-successive game.

Earlier in the day, attacking midfielder Ian Poveda joined on a season-long loan from Leeds United.

The second full month of the campaign began with two new signings: forward Zak Emmerson from Brighton & Hove Albion and midfielder Callum Wright from Leicester City, both for undisclosed fees.

Also leaving, on loan, were forward Ewan Bange (to Queen of the South until January) and midfielder Matty Virtue (to Lincoln City until the end of the campaign).

After a postponement of the planned 10 September home fixture with Middlesbrough, Blackpool lost 3–0 at Rotherham United four days later.

On 17 September, Blackpool lost 2–1 at Millwall, leaving the club 19th in the table before a two-week international break.

A goalless draw at Sunderland on 4 October was followed by a 3–1 victory over Watford at Bloomfield Road, with Jerry Yates scoring twice.

Blackpool travelled to Bramall Lane to face Sheffield United on 15 October, and left with a point after a 3–3 draw.

Jerry Yates scored his third brace in four games, while Charlie Patino and CJ Hamilton also found the net.

A single-goal defeat at West Bromwich Albion on 1 November dropped Blackpool one place to sixteenth.

Midfielder Callum Wright joined Plymouth Argyle for an undisclosed fee on 4 January, while Morgan Rogers signed on loan from Manchester City until the end of the season.

On 11 January, German midfielder Tom Trybull joined the club on a free transfer from SV Sandhausen.

A 2–0 defeat at Watford on 14 January, leaving Blackpool second-bottom, was Michael Appleton's final game in charge.

McCarthy's planned first game in charge, at home to Huddersfield Town on 21 January, was postponed due to a frozen pitch.

Earlier in the day, the club signed defender Curtis Nelson from Cardiff City on a free transfer.

Three days later, Blackpool beat Stoke City by a single goal at Bloomfield Road, Ian Poveda with the strike.

It was their first win in the league since 29 October,[19] and lifted them off the bottom of the table, on goal difference, at the expense of Wigan Athletic.

Blackpool remained 23rd, four points adrift of safety, but bottom club Wigan Athletic had a game in hand.

On 15 April, Blackpool beat fellow relegation candidates Wigan Athletic by a single goal.

Blackpool travelled to Birmingham City on 22 April, and an Ian Poveda goal on 74 minutes proved decisive.

[20] Five days later, Blackpool ended the season with a single-goal victory at Norwich City, with Morgan Rogers scoring the goal in the fifteenth minute.

Released were goalkeepers Chris Maxwell and Stuart Moore, defenders Luke Garbutt, Curtis Nelson and Jordan Thorniley, midfielders Keshi Anderson, Kevin Stewart and Liam Bridcutt, and forwards Beryly Lubala and Gary Madine.

Contract extensions were triggered on defenders Callum Connolly and James Husband, midfielders Kenny Dougall, CJ Hamilton, Luke Mariette, Tayt Trusty and Matty Virtue, and forwards Shayne Lavery and Will Squires.