The 2022–23 CAF Confederation Cup knockout stage started on 23 April with the quarter-finals and ended on 3 June 2023 with the final to decide the champions of the 2022–23 CAF Confederation Cup.
The team that scored more goals on aggregate over the two legs advanced to the next round.
If away goals were also equal, then extra time was not played and the winners were decided by a penalty shoot-out (Regulations III.
The mechanism of the draws for each round was as follows: The knockout stage involved the 8 teams which qualified as winners and runners-up of each of the eight groups in the group stage.
The bracket of the knockout stage was determined as follows: The bracket was decided after the draw for the knockout stage (quarter-finals, semi-finals and final), which was held on 5 April 2023, 18:30 GMT (20:30 local time, UTC+2), at the CAF headquarters in Cairo, Egypt.