The 2022–23 CEV Challenge Cup was the 43rd edition of the third tier European volleyball club competition organised by the European Volleyball Confederation.

[1] The draw was held on 28 June 2022 in Luxembourg City.

[2] Qualification round (Home and away matches): Main phase (Home and away matches): Final phase (Home and away matches): Aggregate score is counted as follows: 3 points for 3–0 or 3–1 win, 2 points for 3–2 win, 1 point for 2–3 loss.

In case the teams are tied after two legs, a Golden Set is played immediately at the completion of the second leg.