The Tigers were led by thirteenth-year head coach Brad Brownell and played their home games at Littlejohn Coliseum in Clemson, South Carolina as members of the Atlantic Coast Conference.

[2] The Tigers would set another program record on February 15, 2023 when they defeated Florida State 94–54 at home.

This was the Tigers' largest victory in ACC play, beating the previous record of a 34 point win in 1975.

[4] Despite being the first seed, and hosting, the Tigers lost to Morehead State in the First Round to end their season.

In the ACC tournament, they defeated NC State before losing eventual champions Virginia Tech in the second round.