The 2022–23 Colorado Buffaloes women's basketball team represented the University of Colorado Boulder during the 2022–23 NCAA Division I women's basketball season.

The Buffaloes, led by seventh year head coach JR Payne, played their home games at the CU Events Center and compete as members of the Pac-12 Conference.

As the fifth seed in the Pac-12 women's tournament they defeated Washington in the first round, Arizona in the quarterfinals before losing to Stanford in the semifinals.

They received an automatic bid to the NCAA Women's Tournament as a 7th seed in the Greensboro Region where they got upset by 10th seed Creighton in the first round.

The Buffaloes were the last undefeated DI women's college basketball in the 2021-22 season, losing their first game to #2 Stanford on January 14, 2022.