[6] Sutton Common Rovers did likewise on 17 May,[7] though this fixture was later cancelled.

[9] Two days later, a home fixture against Queens Park Rangers was confirmed.

[14] On 20 December, Crawley announced they would travel to the training ground of West Ham United to play a behind-closed-doors friendly against their U21 side.

[15] Source: Sky Sports On 23 June 2022, the League Two fixtures were announced for the forthcoming season.

[84] Three days later, Aston Villa U21 joined Southern Group B.