On 19 May, Cruz Azul announced the dismissal of Juan Reynoso as the first team coach, ending his spell at the club after 16 months.

[3] On 7 August, Rafael Baca's contract was automatically renewed until the end of 2023 after reaching an undisclosed percentage of minutes played.

[4] On 4 February, Carlos Vargas made his debut with Cruz Azul and suffered a season-ending torn ACL in his right knee in the 14th minute of play.

Win Draw Loss Fixtures The second edition of the Copa por México will be held with ten Liga MX teams and will serve as a pre-season for the Clausura 2022 tournament.

Sources: Soccerway, Liga MX The list is sorted by shirt number when total clean sheets are equal.