The 2022–23 Cymru South season (also known as the 2022–23 JD Cymru South season for sponsorship reasons) was the fourth season of the second-tier Southern region football in Welsh football pyramid.
Teams played each other twice on a home and away basis.
Llantwit Major were the defending champions from the 2021–22 season but were denied a Tier 1 license, so runners-up Pontypridd Town were promoted in their place.
Barry Town United were relegated from the 2021–22 Cymru Premier, returning to the second tier after their five-year spell in the top flight.
Abergavenny Town and Pontardawe Town were both promoted as champions of the Ardal SE and Ardal SW respectively, while Ardal SW runners-up Ynyshir Albions defeated Ardal SE runners-up Abertillery Bluebirds in the Ardal Southern play-off to also earn a promotion place.