Rhein-Neckar Löwen won their second title with a finals win over SC Magdeburg.

The teams were split into a north and south group.

All 2021–22 Handball-Bundesliga teams received a bye.

[4][5] The matches were played on 19, 20 October, 2 and 22 November 2022.

[10][11] The matches were played on 15 and 16 April 2023 at the Lanxess Arena, Cologne.