The 2022–23 DePaul Blue Demons men's basketball team represented DePaul University during the 2022–23 NCAA Division I men's basketball season.

They were led by second-year head coach Tony Stubblefield and played their home games at Wintrust Arena in Chicago, Illinois as members of the Big East Conference.

They defeated Seton Hall in the first round of the Big East tournament before losing to Xavier in the quarterfinals.

On January 10, 2023, DePaul defeated Villanova for the first time since 2008, snapping a 22-game losing streak to the Wildcats over 15 years.

They lost in the first round of the Big East tournament to St. John's.