Former Hamilton player and assistant manager Stuart Taylor returned to the club after being appointed as their new head coach on 20 August 2021.

[1] Taylor would step down from his role on 23 June 2022 after 10 months in charge.

[2] John Rankin, who had been first-team coach under Taylor, was promoted to the position of head coach 5 days later.

[3] On 20 May 2023, following a play-off draw with Lanarkshire derby rivals Airdrieonians, Hamilton were relegated to League One after losing 5–6 on penalties and dropped down to the third tier of Scottish football for the first time since 2005.

[4] Win Draw Loss Postponed As of 20 May 2023[8]