The Jayhawks, members of the Big 12 Conference, played their home games at Allen Fieldhouse in Lawrence, Kansas.

On November 2, 2022, Kansas announced that Self and assistant coach Kurtis Townsend would serve a four-game suspension for alleged recruiting violations from a 2017 FBI probe.

[3] Redshirt junior forward Jalen Wilson was named First Team All-American by the AP.

They would lose in the second round to Arkansas 71–72 marking the third time in their last four tournament appearances they failed to make the Sweet 16.

Below are players who ran out of eligibility or seniors that did not declare intent for a 5th year as allowed by the NCAA due to the COVID-19 pandemic.