On 20 June 2022, Academica and on 27 June 2022, Gaz Metan was relegated directly to Liga III, by the Romanian Football Federation, which denied a second tier licence to Academica and Gaz Metan, due to important financial problems and unpaid debts to current and former players and managers.
On 8 August 2022, Academica Clinceni and Gaz Metan Mediaş were both excluded from all the competitions organized by the Romanian Football Federation, due to financial problems.
[5] Pandurii Târgu Jiu, Sporting Vaslui, Rapid II București, Hușana Huși, Speranța Răucești and Silvicultorul Maieru withdrew from the competition, before the start of the season.
[5] Politehnica Timișoara and Unirea Constanța was spared from relegation to 2022–23 Liga III season, due to the decision to relegate Academica Clinceni and Gaz Metan Mediaş, decision that vacanted places in the 2022–23 Liga II season.
CSM Bacău, Unirea Alba Iulia, Progresul Ezeriș, Flacăra Horezu, Kids Tâmpa Brașov and Minerul Costești were spared from relegation to 2022–23 Liga IV season, due to the exclusion of Academica Clinceni and Gaz Metan Mediaş and the withdrawn of Rapid II București, Hușana Huși, Speranța Răucești and Silvicultorul Maieru.