[1][2] The reigning champions entering the season are Corteva Cocos who claimed their 2nd league title after winning the 2021-22 final against Majadahonda.

[5][6] They replaced Sanse Scrum who were relegated after nine years in the top flight.

Last placed relegated to Honor Division B. Fixtures for the season were announced by the Spanish Rugby Federation on 26 July 2022.

The team finishing in 7th place faces the runner-up of the Honor Division B, with the winner of this match playing in the 2023–24 Liga Iberdrola and the loser in the 2023–24 Honor Division B.

After the 2022 General Assembly, the Spanish Rugby Federation announced the creation of a new competition, the Women's Super Cup, that would pit Corteva Cocos, as champions of the previous season league and Majadahonda as winners of the regular season, and would act as start of the season.