All rounds were played on a home-and-away two-legged basis, with the higher-ranked team in the classification phase of each tie hosting the second leg.
The quarter-final pairings were pre-determined based on the teams' final position in the classification phase.
In the semi-finals the teams were re-seeded based also on their final position in the classification phase in order to determine the two pairings.
[2] Comunicaciones were the defending champions, having won the Clausura 2022 tournament at the previous season.
[3] Source: Soccerway The final phase of the Apertura tournament ran from 30 November to 18 December 2022.
As Torneo Apertura champions they qualified for the 2023 CONCACAF Central American Cup.
[53] The defending champions were Cobán Imperial, who had won the previous Apertura 2022 tournament.
[54][53] The match schedule was decided based on the draw which took place during the Extraordinary General Assembly of the Liga Nacional held on 20 December 2022.
As Torneo Clausura champions they qualified for the 2023 CONCACAF Central American Cup.