They won the EFL Cup with a 2–0 victory over Newcastle United in the final, the club's first competitive trophy since winning the UEFA Europa League in 2017.

[9] United began the tour with a 4–0 win over Liverpool; goals from Jadon Sancho, Fred and Anthony Martial put them 3–0 up by half-time, before Facundo Pellistri added a fourth less than 15 minutes from the end.

[11] On 19 July, United led Crystal Palace 3–0 first via Martial, Rashford, and Sancho before a goal from Joel Ward pulled one back for the London club.

Named in the starting line-up, Lisandro Martínez and Christian Eriksen made their debuts for United, as did Tyrell Malacia, who came on as a substitute.

Josh Dasilva, Mathias Jensen, Ben Mee and Bryan Mbeumo all scored without reply before the clock had reached 38 minutes.

[21] Erik ten Hag became the first United manager since John Chapman in 1921 to lose his opening two games in charge of the club.

Rashford then scored two goals in order to secure victory against Arsenal, who were on top of the league table, having started the season on a five-match winning streak.

An injury to Martial saw him replaced by Cristiano Ronaldo just before the half-hour mark, who only took 15 minutes to score the winning goal, assisted by Casemiro.

Following a foul in the penalty area by Scott McTominay, Jorginho slotted home the penalty three minutes from time, but Casemiro then headed home in the fourth minute of stoppage time – his first United goal – as United extended their unbeaten league record against the West London side to 10 matches, dating back to November 2017.

[35] A week later United travelled to Aston Villa, in their manager Unai Emery's first Premier League game since his days with Arsenal.

A seventh-minute goal from Leon Bailey and a free kick from Lucas Digne four minutes later gave Villa an early two-goal lead, before a shot from Luke Shaw was deflected into his own net by Jacob Ramsey.

[36] The following Sunday saw United travel to West London to face Fulham for the last Premier League game prior to the World Cup.

Rashford broke the deadlock with a header at the 80th minute following a cross from Shaw, before Garnacho sealed the win with a strike assisted by Weghorst.

The game was goalless heading into added time, before Brighton were awarded a penalty following a VAR review after Luke Shaw was judged to have handled the ball in the area while defending a corner.

Anthony Martial scored a first half tap-in from a square pass by Antony, before Alejandro Garnacho marked his return from injury with a stoppage time goal to strengthen United's grip on 4th place in the league.

The away side went ahead in the first half after a header from Kenny Tete, but missed the chance to double their lead after De Gea saved a penalty from Aleksandar Mitrović.

United then fought back in the second half with Sancho and Fernandes getting on the scoresheet for a comeback win to ensure they would finish the season in third place.

A handball from Willian at the goal line led to a VAR referral, where Fulham manager Marco Silva attempted to influence the referee, which resulted in his dismissal.

Anthony Martial equalised 19 seconds after the ensuing kick-off, only for United to go behind again when Diogo Dalot diverted a ball from Leon Bailey into his own net just after the hour mark.

The match featured Kobbie Mainoo and Facundo Pellistri's competitive debuts for the club; the former started and played for an hour while the latter came on as a substitute at 84 minutes and assisted Rashford's first goal.

[83] In the return leg, goals from Anthony Martial and Fred secured a 5–0 aggregate win and a final appearance against Newcastle United.

They entered the competition in the group stage, which was drawn on 26 August 2022, with United in Pot 1 along with Roma, Arsenal, Lazio, Braga, Red Star Belgrade, Dynamo Kyiv and Olympiacos.

[86] They were drawn into Group E with Spanish club Real Sociedad, Moldovan champions Sheriff Tiraspol and Cypriot representative Omonia.

[88] Before United's opening group match at home to Real Sociedad, a moment of silence was observed following the death of Queen Elizabeth II earlier that day.

Real Sociedad's Brais Méndez scored the only goal of the game from the penalty spot after 59 minutes, following a contentious handball decision against substitute Lisandro Martínez, to give the Spanish side their first ever win over United.

Half-time substitutes Rashford and Martial put United 3–1 up before Nikolas Panayiotou scored a late consolation goal for the hosts.

There were no other English teams in the draw conducted on 7 November 2022, so all eight opponents were possible: Ajax, Barcelona, Bayer Leverkusen, Juventus, Red Bull Salzburg, Sevilla, Shakhtar Donetsk and Sporting CP.

However, former Leeds United winger Raphinha, who assisted Alonso for the first goal, scored himself 14 minutes from full time as the teams settled for a 2–2 draw.

Second half goals from Brazilian duo Fred and Antony turned around the match and tie as United secured only their fourth competitive win over Barcelona, and the first since the 2007–08 UEFA Champions League semi-finals.

With six minutes left, Tyrell Malacia deflected a cross from former Manchester City winger Jesús Navas into his own net, and when Lisandro Martínez was injured shortly after, United were forced to play with 10 men, having already used all five substitutions.