The Spartans were led by 28th-year head coach Tom Izzo and played their home games at Breslin Center in East Lansing, Michigan as members of the Big Ten Conference.

On August 11, 2022, the school announced that it had signed Izzo to a five-year $31 million contract extension making him one of the highest-paid coaches in the nation.

7 seed in the West region, marking MSU's 24th straight trip to the NCAA tournament, the second longest active streak.

[12] On June 3, the school announced that former MSU player and graduate assistant Thomas Kelley had been hired to replace Stephens.

[16] On March 26, 2022, senior forward Gabe Brown announced he would not return to MSU to take advantage of an extra year of eligibility granted by the NCAA due to the COVID-19 pandemic and declared for the NBA draft.

[26] On April 20, forward Joey Hauser announced he would return to MSU, taking advantage of the extra year of COVID-19 eligibility.

[30] Sources: Prior to the conference's annual media day, unofficial awards and a poll were chosen by a panel of writers.

[33] Prior to the first official practice of the year, it was announced the forward Malik Hall had a toe injury and would miss a couple of weeks.

[39] MSU, still without Jaden Akins, started AJ Hoggard, Tyson Walker, Hall, Joey Hauser and Mady Sissoko.

[40] The Spartans beat the Lumberjacks easily 73–55 as Joey Hauser scored 18 points and added 10 rebounds in the easy win.

But Tyson Walker, who scored 12 points and added three assists, slipped twice on the final play leaving Jaden Akins to take an off-balance three-pointer as the clock ran out and the Spartans lost 64–63.

On the ensuing inbound play, Malik Hall found himself wide open in front of the basket for a dunk to tie the game and force overtime.

Taking the ball out from under the Kentucky basket, Hoggard hit Walker breaking down the court who found Hall and was again wide open for a dunk to tie the game.

In the second overtime, UK went up 76–73 before the Spartans closed the game on a 10–0 run including two dunks from Mady Sissoko on an assists from Walker.

Walker made one of two free throws to push the lead to two with 16 seconds left and Villanova was forced into a long three-point attempt as the clock expired that fell short.

Prior to the game, the team announced the Malik Hall would be sidelined for about three weeks with a stress reaction in his left foot.

The Pilots pulled away for an eight-point halftime lead, but the Spartans responded in the second half with 10 straight points to erase the deficit.

With a chance to tie it, AJ Hoggard forced a tough shot and punched the rebound out of the lane as the clock ran out to give MSU the 78–77 win.

The now 20th-ranked Spartans traveled to South Bend, Indiana to face Notre Dame on November 30 as part of the ACC–Big Ten Challenge.

It was announced on November 28 that the challenge would not be renewed after the season due in large part to the Big Ten's new television contract with FOX.

Malik Hall scored 11 in his return including a highlight reel dunk in the first half while Jaden Akins led the Spartans with 12 points.

MSU started well, keeping the game close, but Zach Edey continued his good play against the Spartans as Purdue pulled away to 40–22 lead at half time.

Hoggard made two late free throws and was able to pass out of a full-court press to find Jaden Akins for a dunk with four seconds remaining to give MSU the 63–58 win.

Jaden Akins missed all six of his attempted three-pointers, but grabbed nine rebounds as the Spartans won back-to-back games for the first time since January 10.

In a show of solidarity with MSU, Michigan held a moment of silence for the shooting victims and the band played the Spartan alma mater before the game.

After the heartbreaking loss against Iowa in the prior game, the Spartans started off extremely slow and fell behind by as many as 15 in the first half against the Cornhuskers.

MSU would lead for the remainder of the first half against a Marquette team whose starting point guard, Tyler Kolek, had suffered a thumb injury in their first round game against the 15-seeded Vermont Catamounts two days prior.

KSU point guard Markquis Nowell set an NCAA tournament record with 19 assists in the game and the Wildcats led by four with 1:07 remaining in the half.

After calling a timeout with 12 seconds remaining, the Spartans were unable to get off a shot and Nowell stripped Walker for layup as time expired to seal the 98–93 win.

[93] On July 13, MSU and Gonzaga announced that they would play a game on the aircraft carrier USS Abraham Lincoln on November 11 as part of a Veteran's Day celebration.