The regular season commenced 30 November 2022 and ended 19 April 2023 with the playoffs taking place from 6 to 11 June 2023.
Heartland Queens and Ibom Angels were promoted from the NWFL Championship replacing Sunshine Queens and Pelican Stars who were relegated the previous season.
Alongside Osun Babes, Ibom Angels failed to retain their place and returned to the Championship.
[3] On 11 June, Delta Queens defeated defending champions Bayelsa Queens at the super six final to claim their sixth title and earn the right to play at the 2023 CAF Women's Champions League.
The top teams from both groups played a final match to decide the champion who also earns the right to play at the 2023 CAF Women's Champions League regional qualifying stage.