The 2022–23 Nicholls Colonels women's basketball team represented Nicholls State University during the 2022–23 NCAA Division I women's basketball season.

The Colonels, led by fifteenth year head coach DoBee Plaisance, played their home games at Stopher Gym located in Thibodaux, Louisiana as members of the Southland Conference.

They failed to qualify for the 2023 Southland Conference women's basketball tournament.

They participated in the 2022 Southland Conference women's basketball tournament as the No.

Receiving 25 votes overall, the Colonels were picked to finish tenth in the conference.