The Wildcats played their home games at Welsh–Ryan Arena in Evanston, Illinois as members of the Big Ten Conference.

This season was also notable as the first time Northwestern defeated a number-one ranked opponent, during a home game against Purdue on February 12.

[2][3] The Wildcats' originally scheduled game against Iowa on January 18, 2023 was postponed due to COVID-19 protocols within the Northwestern program.

[5] On February 11 Northwestern defeated Purdue, earning its first-ever victory over an AP poll number one-ranked team.

[6] In the subsequent game on February 15, Northwestern established a school record with its fourth victory of the season over a ranked opponent by defeating 14th-ranked Indiana in a rematch.