The 2022–23 Oklahoma State Cowgirls basketball team represented Oklahoma State University in the 2022–23 NCAA Division I women's basketball season.

The Cowgirls, led by first year head coach Jacie Hoyt, played their home games at Gallagher-Iba Arena and were members of the Big 12 Conference.

The Cowgirls finished the season 9–20 overall and 3–15 in the Big 12 conference.

At the end of the regular season, Oklahoma State and head coach Jim Littell mutually agreed to part ways, but continued to coach through the Big 12 Tournament.

[1] On March 20, Jacie Hoyt was introduced as the new head coach.