The Rebels, led by fifth-year head coach Yolett McPhee-McCuin, played their home games at The Sandy and John Black Pavilion at Ole Miss and competed as members of the Southeastern Conference (SEC).

The Rebels were selected to the NCAA Tournament in the Seattle regional, defeating Gonzaga 71-48 in the first round.

They then advanced to the second round where they had a big upset over 1-seed Stanford, winning 54-49 to advance to the Sweet Sixteen for just the second time in program history (They had previously made it that far in 2007, when Carol Ross coached the team to the Elite Eight).

They lost to Louisville 72-62 and finished the season ranked #22 in the Coaches Poll.

The Rebels finished the season 23–9 (10–6 SEC) and received an at-large bid to the NCAA tournament, where they lost to South Dakota in the First Round.