The reigning champions entering the season were Leicester Tigers, who claimed their 11th league title after winning the 2022 final.

[9] On October 28, it was confirmed that Wasps had been suspended for the remainder of the season and relegated – their results were subsequently deleted from the Premiership's records.

[15] Worcester Warriors were suspended from all competitions on 26 September 2022 and then expelled on 6 October 2022, reducing the league to 12 teams.

[24] The league season began on 10 September 2022, a day later than first scheduled, after the opening night fixtures were postponed by 24 hours following the death of Queen Elizabeth II.

[28] However, after the removal of Worcester Warriors and Wasps from the league, several teams experienced extra bye weeks due to the cancellation of fixtures against those two clubs.

In response to the disrupted schedule, Premiership Rugby announced a revised fixture list for the second half of the season on 11 November 2022.

[39] The dates and times for the two play-off semi-finals were announced on 23 April 2023, after the qualifying teams were confirmed at the end of the regular season's penultimate round.

Player of the Match: Owen Farrell (Saracens) Assistant referees: Karl Dickson Christophe Ridley Television Match Official: Tom Foley Note: Flags to the left of player names indicate national team as has been defined under World Rugby eligibility rules, or primary nationality for players who have not yet earned international senior caps.

Note: Points or tries scored in fixtures involving Wasps or Worcester Warriors are not included, after Premiership Rugby expunged these results from record, following the expulsion of both clubs from the league.