The 2022–23 Purdue Fort Wayne Mastodons men's basketball team represented Purdue University Fort Wayne in the 2022–23 NCAA Division I men's basketball season.

The Mastodons, led by ninth-year head coach Jon Coffman, played their home games at the Hilliard Gates Sports Center in Fort Wayne, Indiana, as members of the Horizon League.

9 seed in the Horizon League tournament, they lost to Detroit Mercy in the first round.

The Mastodons finished the 2020–21 season 21–12, 15–6 in Horizon League play to finish in a tie for first place, earning a share of the Horizon League regular season championship.

2 seed in the Horizon League tournament, they defeated UIC in the quarterfinals before losing to Northern Kentucky in the semifinals.