On 25 March 2022, Queen's announced the appointment of Owen Coyle as their new head coach who would take up the position from June 1st.

[2] On 25 May 2022, Queen's announced the team would play their League Cup home ties at Ochilview Park, as the redevelopment of Lesser Hampden was unable to be completed before the start of the new season.

[3] On 13 June 2022, the club started a new initiative to facilitate and stimulate the further flow of academy players.

Starting from this season, the first team will be playing with a development team, Young Queen’s Park.

[4] Win Draw Loss Postponed Queen's Park initially progressed to the fifth round of the Scottish Cup, but were expelled from the competition after fielding an ineligible player in their fourth round match with Inverness.