The Cougars, led by fourth-year head coach Brian Barone, played their home games at the First Community Arena in Edwardsville, Illinois as members of the Ohio Valley Conference.

Guard Ray’Sean Taylor and forward DeeJuan Pruitt were named to the 10 member 2022-23 Preseason All-OVC Team.

[6] Defending Horizon League champion Purdue Fort Wayne took a double digit first half lead on the Cougars with a barrage of 3 point buckets.

SIUE made a comeback in the second half, cutting the lead to three before the Mastodons' long range shooting locked up their win.

[7] On November 14, the Ohio Valley Conference named Damarco Minor the OVC Newcomer of the Week for his play in games against Harris Stowe and Purdue Fort Wayne.

[9] In their opener of the JK54 Classic round robin tournament, there were 18 ties and 13 lead changes before SIUE beat Fairleigh Dickinson 79-78 on a 10-foot turnaround-jumper with 6.5 seconds to play by Lamar Wright.

Damarco Minor's 22 points led four Cougars in double figures, and Jonathan Kurtas had his first career double-double (13 pts, 10 rebounds.)

[12][13] Cougar redshirt-sophomore guard Ray'Sean Taylor is one of 50 players from the 21 so-called "mid-major" conferences named to the Lou Henson Award Watch List.

In the final two and a half minutes, SIUE finished on a 9-1 run while holding Kansas City to only a single free throw, to close out the 64-54 win.

[17][18] Ray'Sean Taylor's last second over-the-shoulder shot went in, but the final buzzer sounded while it was still in the air, and the Bradley Braves won 56-54 to stop the SIUE win streak at six games while extending their own to four.

[19] For their second consecutive Missouri Valley Conference opponent, the Cougars visited the Illinois State Redbirds for their Return to Horton Fieldhouse to honor ISU alumnus Doug Collins.

Despite losing, four Cougars scored in double figures; Ray'Sean Taylor' - 20, Shamar Wright -12, Terrance Thompson -11, Jonathan Kurtas -10.

[20] The Division III Scarlet Hawks of IIT, coached by former Cougar Terrance "T.J." Gray, visited First Community Arena.

Fourteen years after graduating, T.J. Gray still holds the SIUE record for 3 point baskets in a season, and his team played the same way, shooting 15-32 from outside the line to keep the Cougars from blowing them out of the gym.

Slowly, the lead shrank, until DeeJuan Pruitt sank a pair of free throws to tie the game at 66 with only 1:06 remaining.

Stymied in the first half, Ray'Sean Taylor scored 9 of his 12 points in the second, including the Cougars' last three to lock up the win.

[23] The Cougars shoot only 35% from the field during the first half at Southeast Missouri State but stayed within five points at halftime by going 11-11 from the free throw line.

Striving to maintain its unbeaten home record, the Screaming Eagles hit five three-pointers early in the game for a 19-15 lead.

DeeJuan Pruitt continued his domination of the Panthers with his sixth career double-double--- a career-high 24 points and tying his season high 13 rebounds.

Taylor led the team with a season high 6 assists, "...big time," coach Brian Barone declared.

[28] Located only 32 miles apart,[29] their first meeting as Ohio Valley Conference opponents was their first since 2005, when SIUE was in Division II and Lindenwood in the NAIA.

The Cougars led from start to finish in the 68-58 win, but the Lions kept them close in front of SIUE's largest home crowd of the season.

Double-teamed the entire game, DeeJuan Pruitt scored only five points but got his season high thirteen rebounds for the third time.

Ray'Sean Taylor's season high 24 points and DeeJuan Pruitt's 11 could not offset the five Morehead State players in double figures.

[32] Thirty points and five steals by Ray'Sean Taylor and DeeJuan Pruitt's eighth career double-double were not enough to hold off hot shooting Tennessee Tech, who gave the Cougars their third consecutive loss.

[34] Hosting OVC co-leader Tennessee Martin, the Cougars opened with a 14-2 blitz and never looked back on the way to snapping their four game losing streak.

Ray'Sean Taylor again led the way with 27 points and 10 rebounds for his first double-double of the season, adding four assists and two steals to his stat line.

Taylor took one dribble and put up a sixty foot shot that hit the back of the rim and dropped through the net for the 84-81 win.

After getting their act together, the Cougars closed to 30-28 at the break,and tied the game with the first basket of the second half, a DeeJuan Pruitt layup.

[40] The Cougars and Tennessee State started out pretty much playing even, but the Tigers' Junior Clay was on fire, scoring 40 points as he led his team to a 100-85 win.