The winter break began earlier than usual this season due to the 2022 FIFA World Cup in Qatar, with the last full round scheduled for 11–13 November 2022.
Slovan Bratislava successfully defended their title, securing a record-extending fifth consecutive championship.
Liga, replacing Pohronie (relegated after three years in the top flight), who finished last in the 2021–22 Slovak First Football League.
As a result, a playoff was held for the final spot in the Europa Conference League, which involved the teams ranked in 4th–7th place at the conclusion of the regular season.
Žilina won the play-offs and earned a place in the Europa Conference League first qualifying round.